Rapid Diagnostic Tests: Call For Innovations

Rapid detection of Ebola infections in the field or at decentralised healthcare centers is an urgent need in the current crisis of the outbreak of EVD and will remain important even after the current crisis may have subsided. Additional technologies addressing various healthcare facilities settings will also be important to maintain surveillance in the long term. Current PCR-based tests have a number of limitations related to time and procedures requiring infrastructures and specific training. Tools and technologies are needed to provide quality diagnostics at low cost. Several such tests are already under development but their performance and practicability are unknown.

The scientific committee will discuss and present critical questions :

1-How a rapid diagnostics can detect EVD at acceptable costs and with very high sensitivity and specificity. At a minimum a rapid diagnostic test should be able to be deployed at decentralised health care facilities under conditions with minimum laboratory infrastructures available.

2-How to develop a phase of clinical validation in the field under real-world conditions ?

3- How to address manufacturing and access path to ensure sustainable distribution including taking into account ethical considerations and the health systems context.

4-How to meet the following practical solutions that meet the following criteria:

  • Very high sensitivity and specificity
  • Ability to be deployed in resource-limited settings
  • Minimal training required to operate
  • Capability of multiplexing in order to include different ebola strains
  • Time to result 15-30 minutes (desirable) – 3 hours (acceptable)
  • Sample type for intake: blood (capillary fingerstick desirable), other less invasive sample types (urine, saliva, etc.)


For more information: www.targeting-ebola.com